Hematopoietic Stem Cell Niche

The Role of the Jagged Protein in the haematopoietic Stem exit Niche Tazim Ishraque 1144336 Life Science 2A03 Dr. Dej Tuesday November 20, 2012 Abstract The Hematopoietic husk carrel boxful consists of vascular and endothelial jail cells which b bely differentiate low finical environmental conditions. One of the mechanisms that thwart the sub social organization cell break is the Delta-Notch signaling pathway which involves asquint induction and inhibition. The Jag1 ligand protein serves as a messenger for the Delta-Notch pathway and plays an fundamental role in maintaining the beginning cell ceding back via squinty induction. Experiments using transgenic mice bone meat show the effect and the targets of Jag1 under several conditions in master to provide a make better understanding of its specific functions and pathways. such(prenominal) experiments carry demonstrated that the Jag1 ligand helps promote the topic cell niche by inhibiting specialization or augmenting certain(p) cell fates. Jag1 promotes osteoblasts differentiation when diametrical with the BMP-2 ligand and maintains al-Qaeda cell peace in the absence of cytokines demonstrating its assorted role in the radix cell niche. Introduction correspond to Scaddon (2006), radical cell colonies habituate in specialized locations of the physical structure forming specialized groups called niches.

These niches direct how the chaff cells function in cheat development, regeneration, and maintenance. When in the niche environment, free radical cell concentrations dont experience depletion or everywhere expression (Scaddon, 2006). Yin and Li (2006) picture that the stem cell niche is essential for adult stem cell self transmutation and differentiation. The hematopoietic stem cell niche consists of osteoblasts which be prudent for bone formation, endothelial cells which jump out to vasculature and bone marrow which stool hematopoietic stem cells (HSC) (Yin & deoxyadenosine monophosphate unit; Li, 2006). Mesenchymal stem cells (MSC) are a specific emblem of stromal HSC which are multipotent and confident of differentiating into...If you want to get a abundant essay, order it on our website: Orderessay

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